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Caffeine increases the activity of the Na + K + pump to exert effects peripherally, enhancing the excitationcontraction coupling necessary for muscle contraction, which contributes to improved physical performance

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Researchers also raised concerns about users combining Melanotan with other image-enhancing drugs, increasing the chance of harm

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- Nausea or stomach upset (common with oral supplements) - Mild skin rashes or itching (possible with topical use) - Temporary bloating or cramping These are usually mild and subside when dosage is adjusted or discontinued