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Insert the needle through the tirzepatide vial stopper at a slight angle

The LEADER trial demonstrated cardiovascular benefit comparable to what semaglutide would later show in SUSTAIN-6, though with a somewhat smaller magnitude of effect

Figure 3: Head-to-head efficacy comparison restricted to Standard-design, Non-T2D trials

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Some studies have also shown the presence of GLP-1Rs in mood-related brain regions and demonstrated its powerful role in emotional processing within the CNS (Merchenthaler et al., 1999

Pooled analysis showing significant and safe weight loss across trials