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Comprehensive management of tophi requires sustained, effective urate-lowering therapy, with serum urate levels maintained below 0.30 mmol/L to reduce overall crystal burden (197)

Alternative GLP-1 receptor agonists with different formulations or injection frequencies may be considered if local reactions significantly impact treatment adherence

Wegovy diarrhea as a side effect Wegovy, another semaglutide-based medication, shares a similar side effect profile with Ozempic, including the potential for diarrhea

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