How Mounjaro works Mounjaro is a once-a-week injection containing the drug tirzepatide
A blinded extension among participants with baseline BMI 35 reached 30.3% mean weight loss at 104 weeks
GI events (nausea, vomiting, diarrhea) were the dominant safety signal and occurred at rates higher than reported for Phase 2 retatrutide and higher than for comparable dual or mono-agonist trials
Funding: This study has been funded by Heart and Stroke Foundation of Canada and that the funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript
Stacked graphs refer to different cell state: viable (AnnexinV PI cells), early apoptotic (AnnexinV + PI cells), late apoptotic (AnnexinV + PI + cells), apoptotic (AnnexinV PI + cells)
B12 deficiency specifically causes fatigue, weakness, and cognitive fog that mimics the worst aspects of retatrutide tiredness