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usually present from childhood with a positive family history

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In 2014, the GLS inhibitor CB-839, undergoing clinical trials, was reported to possess potent anti-tumor activity, offering a novel avenue for targeted cancer therapy through modulation of glutamine metabolism [14]

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Useful as supporting evidence but not diagnostic alone

4 Trauma and post-inflammatory pigmentation Any repeated micro-trauma to a specific point on the lip (a habitual lip-biting spot, friction from a tooth, a healed cold sore, an old burn from hot food or drinks) can trigger localized post-inflammatory hyperpigmentation that stabilizes into a melanotic macule