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While the combination of hormone replacement therapy and GLP-1 based medications shows strong early promise, much of the current evidence focuses on short-term weight outcomes rather than long-term effects on cardiovascular health, cognitive function, and overall healthspan Future research will need to be more precise

10.3389/fimmu.2023.1303605 48 JinX.DingD.YanY.LiH.WangB.MaL.et al (2019)

Ma S, We L, Yang H et al (2017) Emerging technologies to achieve oral delivery of GLP-1 and GLP-1 analogs for treatment of type 2 diabetes mellitus (T2DM)

The severity of gastrointestinal effects varied with dosage, ranging from mild gastric erosion and vomiting to severe ulceration, hemorrhage, and epithelial necrosis