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It also upregulated heme oxygenase-1 (HO-1) and other antioxidant pathways, likely through HIF-1 activation, thereby reducing oxidative stress (135)

GLP-1 medications amplify these effects during dose escalation because both drugs slow gastric motility and increase satiety signaling

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5.6.5 Follow-up duration and attrition Median follow-up is 12 weeks (range 452 weeks), whereas progression/regression of DN typically manifests over years