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A comparison of our Sas Pcob structure with other photocobilin proteins (predicted structures obtained from the recently published Alphafold2 database 26 ), shows they can be divided into three main groups depending on the location of the AdoCbl-binding domain at either the N- or C-terminus, and whether they contain the additional output domain in the fused proteins (Supplementary Figs

TIER PLANS TIER 1 (5mg total) $225 total for 8-10 week supply Monthly cost breakdown: $90-$112 based on weekly dose Recommended if new to treatment or for those on 0.2-0.6mg/week TIER 2 (15mg total) $285 total for 10 week supply Monthly cost breakdown: $114 Recommended for those on 0.7-1.5mg/week TIER 3 (20mg total) $305 total for 8-10 week supply Monthly cost breakdown: $122-$152 based on weekly dose Recommended for those on 1.6mg/week and up TIER 4* (30mg total) $380 total for 8-10 week supply For patients approved to be on high dose therapy of 3-4mg per week Monthly cost breakdown: $152-$190 based on weekly dose TIER 5* (40mg total) $460 total for 8-10 week supply For patients approved to be on high dose therapy of 4-5mg per week Monthly cost breakdown: $184-$230 based on weekly dose EXTENDED PLANS Foundation Plan (15mg total) $300 total for 3-4+ month supply Monthly cost breakdown: $75-100 Recommended if new to treatment or for those on up to 1.25mg/week Momentum Plan (30mg total) $390 total for 4+ month supply Monthly cost breakdown: $97 Recommended for doses up to 1.9 mg/week Elevate Plan (40mg total) $475 for 4+ month supply Monthly cost breakdown: $118 Recommended for doses of 2mg/week & up MONTHLY PLANS Monthly Starter Dose $149 total for one month supply Recommended if new to treatment or for those on 0.6mg/week or less Monthly Mid Dose $159 total for one month supply Recommended for doses up to 1.25mg/week Monthly Advanced Dose $189 total for one month supply Recommended for doses of 1.3mg/week and up Red Rock Pharmacy - Semaglutide/B12 Injection & Semaglutide/Glycine Injection Up to 90 days BUD

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Inject into the front or outer surface of the thigh, in the middle third between hip and knee