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These commenters stated that the burden of reporting these measures outweighs the benefits, highlighting challenges in implementation such as a lack of infrastructure, training, and staff capacity to collect and act on the data meaningfully

Intriguingly, Ying et al

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Indeed, increased activities of ThDP-dependent dehydrogenases (assayed in vitro ) are known as a compensatory response to their in vivo inhibition (38, 150)

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