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Human trials must account for variables such as sex-specific pharmacokinetics, age-related renal decline, and gut microbiota diversity, which modulate therapeutic response

Alternatively, it might be attributed to a worsening, coexisting illness

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Joseph GA, Wang SX, Jacobs CE, Zhou W, Kimble GC, Tse HW, et al

Good exercise options include walking, jogging, cycling, swimming, strength training, HIIT, or dancing

Getting off anti-obesity drugs too quickly also can cause unpleasant withdrawal effects, and many gain back the weight