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Supporting healthy nervous, respiratory, and gastrointestinal systems*

Small-molecule fluorescent probes have gained increasing attention since the emergence of calcium and zinc probes 13,14

Treatment initiation may be accompanied by closer clinical follow-up, lifestyle advice and increased patient engagement, which may influence suicide risk independent of GLP-1 RA effects

As a result, coverage of GLP-1 drugs for the treatment of obesity remains optional for states, while coverage is required for drugs approved for the treatment of diabetes and, since March 2024 and December 2024, for the treatment of cardiovascular disease (Wegovy) and moderate to severe obstructive sleep apnea in adults with obesity (Zepbound), respectively (Table 1)

The extremely low bioavailability of Rybelsus (12%, [47]) is the additional problem and it underlines the need for more efficient and innovative approaches