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Pathway enrichment analysis of these differentially prevalent metabolites revealed significant perturbations in metabolic networks including branched-chain aminoacids degradation, glutathione metabolism, threonine and 2-oxobutanoate degradation, gluconeogenesis, pyruvate metabolism, and glycine and serine metabolism (Figure S5)

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18 Therefore, the FDA has requested the establishment of a cancer registry to monitor the annual incidence of MTC over the next 15 years

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