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It's filled out about a patient, it's scored by you or the patient, and you could identify the phenotype and then target your treatment directly to what the issues are that patient is facing
Losing weight too quickly increases the likelihood of bile thickening and gallstone formation
The mechanisms involve modulating key transcription factors, such as SREBP-1, which controls de novo lipogenesis, along with downregulating enzymes linked to lipid synthesis, such as ACC and FAS (Lyons and Beaudry, 2023)
The SURMOUNT-1 trial showed participants losing up to 22.5% of their body weight on the highest dose of tirzepatide, while STEP 1 trial data for semaglutide showed average losses around 14.9%
Consequently, the development of kidney-specific antisense oligonucleotide (ASO) or adeno-associated viral (AAV) transduction methods is advantageous, as these approaches can selectively inhibit ANGPTL4 in proximal tubules, glomerular podocytes, and glomerular endothelial cells, thereby avoiding the adverse systemic effects associated with whole-body ANGPTL4 loss (Srivastava et al., 2024)
