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Altogether, these findings suggest that certain -KG competitors including DM-succinate and ITA recapitulate -KG insufficiency to inhibit the YBX1AMPK axis in human cells, reinforcing the importance of -KG as an epigenetic cofactor for energy sensing

Tirzepatide has also demonstrated superior efficacy compared to any other therapy used in the treatment of T2DM, comparable or superior even to regimes based on the use of multiple pharmacological classes

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doi: 10.1177/1179546817694558

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