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Some guidelines recommend holding GLP-1 receptor agonists before procedures requiring sedation or general anesthesia to reduce the risk of aspiration, though specific recommendations may vary based on the procedure type and individual patient factors

Gonalves et al

Managing Side Effects and Optimizing Combination Therapy Gastrointestinal symptomsnausea, constipation, or diarrheaare the most common side effects when metformin and GLP-1 drugs are used together