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When examined closely, it was observed that a 2-fold increase in LC3 staining occurred at multiple concentrations that demonstrated at least 90% viability, indicating that the LC3 response occurred at non-toxic or minimally toxic concentrations

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11 While this is a rare adverse effect (ranging from one in 1,000 to one in 3,000 people), this should be discussed with patients before initiating treatment, with advice provided on the symptoms and signs of DKA and when to seek medical attention to get their blood ketones checked (i.e

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