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Janus kinase inhibitors (JAKi) including tofacitinib and baricitinib modulate SLE pathogenesis via JAK/STAT pathway inhibition, with preclinical evidence revealing tofacitinibs dual capacity to reduce NET burden and restore endothelial homeostasis in MRL/lpr models (148150)

The authors of a 2023 review attributed this to the positive effect ALA had on fasting blood sugar levels and insulin resistance Other conditions Various studies have assessed the use of ALA in the treatment of: However, research in these areas is limited

Whether it explains the reports in clinic remains an open question

The medication works by mimicking the naturally occurring GLP-1 hormone, which enhances glucose-dependent insulin secretion, suppresses glucagon release, slows gastric emptying, and reduces appetite

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