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In some embodiments, the otic formulation or composition comprises about 18% by weight of the poloxamer

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Further studies can be carried out to confirm the long-term safety of nasal formulation

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Although an expected reduction in vasopressor requirement was observed with exogenous Ang II administration in the ATHOS-3 trial [28], some patients did not have this vasoconstrictive response, leading to the hypothesis that peptidases, such as DPP3, could be involved in the lack of response to exogenous Ang II [12, 29]

doi: 10.1189/jlb.69.6.986 152 GarciaAFLopesJLCosta-FilhoAJWallaceBAAraujoAP