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Alterations in the volume of distribution and clearance resulting from other mechanisms of action (eg, reduced fat mass, changes in cytochrome P450 activity, and glomerular filtration rate) are key factors in determining pharmacokinetics

Sensitization can be quantified according to the degree of positive patch test reaction (+ to +++), patch test concentration threshold defined by dilution series, and finally by the "Use test"

Ethics statement The studies involving humans were approved by The Third People's Hospital of Bengbu Affiliated to Bengbu Medical University

Qin L, Chen S, Flood E, et al

Additional References Nauck MA, DAlessio DA

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