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The mean change in weight at 72 weeks was 35.5 lb with the 5 mg dose, 48.9 lb with the 10 mg dose, and 52 lb with the 15 mg dose

When IGF-1 LR3 binds to the extracellular alpha subunits of IGF-1R, it triggers a conformational change that brings the intracellular beta subunits into close proximity, enabling trans-autophosphorylation of multiple tyrosine residues on the beta subunits' kinase domains