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Our analysis showed significantly reduced levels of 18:2n6, 20:2n6, 20:3n6, and 22:4n6 fatty acids in rod Igf-1r / mouse retina compared with wild-type retina (Fig

Fat bodies were dissected, whole-mounted on glass microscope slides and imaged using Nikon eclipse 80i microscope fitted with a R1 Retiga Q Imaging camera

The concentrations ranged from 0.001 to 10 mM for ABTS, from 0.02 to 24 mM for DMP, from 0.2 to 60 mM for guaiacol and from 0.025 to 0.35 mM for sinapic acid

Several preclinical studies have shown that lanifibranor has both antifibrotic and positive metabolic effects