This gap in knowledge is why regulatory guidance advises against use during lactation, even though documented harm has not been reported
Missing data was replaced by the mean when possible (see supplemental Table S11) eGFR was calculated using MDRD formula without race consideration: GFR, in mL/min per 1.73 m 2 = 175 SCr (exp[1.154]) Age (exp[0.203]) (0.742 if female)
Because the study was observational, it cannot establish a direct cause-and-effect relationship
Free Radical Bio Med 30:11911212 Schnaubelt D, Queval G, Dong Y, Diaz-Vivancos P, Makgopa ME, Howell G, De Simone A, Bai J, Hannah MA, Foyer CH (2015) Low glutathione regulates gene expression and the redox potentials of the nucleus and cytosol in Arabidopsis thaliana
S.HauserS
The optimal choice depends on specific research goals