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Follow-up after 48 weeks following the end of treatment revealed a significant recurrence of NASH in those who had previously recovered with a serum transaminase and histology similar to the baseline [60], suggesting the need for lifelong therapy

The semaglutide group had a 0.33 percentage point reduction in HbA1c ( P = .034), a 0.37 mmol/L decrease in total cholesterol ( P = .04) and a 0.29 mmol/L decline in LDL cholesterol ( P = .05) from baseline to 1 year

This is called metabolic adaptation

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Currently in clinical trials, a cream with the drug ivermectin has been shown to clear bumps in as little as four weeks

For overall recovery including body composition goals, GH or GH secretagogues might be considered