In the last decade, studies on the condition of BBB in neurodegenerative diseases, including ALS, have demonstrated the presence of vascular disruption, a condition that could theoretically favour the entry of drugs into brain regions affected by neurodegeneration
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Waterhouse EG, An JJ, Orefice LL, Baydyuk M, Liao GY, Zheng K, et al
Buxton ILO (2006): Pharmacokinetics and pharmacodynamics: the dynamics of drug absorption, distribution, action, and elimination
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