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Heydari et al., 2004

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Additionally, P9 induces interleukin-6 (IL-6) secretion from the intestine, which subsequently stimulates GLP-1 secretion by intestinal L-cells and pancreatic -cells, and also affects Icam2 mRNA expression, which suggests the normal expression of Icam-2 and the effects of P9 in glucose homeostasis may require IL-6 [160] (Fig

Future RCTs should focus on increasing representation from underrepresented populations and real-world observational studies in diverse geographic settings to complement RCT data by evaluating treatment effects in broader clinical contexts

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