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Conclusion: Meeting the moment The GLP-1 market is expanding rapidlyand so is the pressure on manufacturers to scale quickly

Injectables generally provide more predictable systemic exposure and have the strongest evidence for substantial, sustained weight loss

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Of note, almost half of patients treated with GLP-1-RAs also had pre-existing migraine as comorbidity (26.7% in the UCWM group), which could predispose them to worse (rather than better) headache outcomes [31], providing additional evidence of a favorable effect of GLP-1-RAs on headache improvement

Citation: Wagih NF, El-Sheikh AA (2021) The Potential Role of GLP-1 Analogues in Cardiovascular Disease Outcomes

161 The trials involved adult participants with T2DM aged 18 to 75, conducted across 42 research and medical centers in the United States