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Specific medications require different washout periods (e.g., semaglutide should be discontinued at least 2 months before a planned pregnancy)

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46 Adverse Effects and Tolerability of GLP-1RAs in Clinical Practice Although the cardiovascular benefits of GLP-1RAs are significant, their use is commonly associated with well-characterised adverse effects that can affect tolerability and long-term medication adherence, as detailed below

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Challenges of insulin therapy include weight gain, the need for education and titration for optimal efficacy, risk of hypoglycaemia, the need for regular glucose monitoring, and cost

The analysis included 6 randomized controlled trials, 1 prospective open-label trial, and 3 observational studies