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In fibroblasts, Vitamin D supplementation has been shown to block the p38 MAPK pathway, thereby reducing the expression of inflammatory cytokines such as IL-6 and IL-8 that are associated with the senescence-associated secretory phenotype (SASP) [203]

For example, the antibiotic chloramphenicol can interfere with the effects of vitamin B, reducing the expected hematologic response to B therapy

However, it is generally more challenging for vegans and vegetarians to obtain adequate B12 solely from plant-based sources

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Spaggiari et al., 2017)

The most important factor is choosing a consistent time that promotes adherence