April 4, 2025
Clinical assessments were conducted every 3 months to evaluate efficacy, measured as percentage of total weight loss (%TWL), excess weight loss (%EWL), changes in BMI, and improvement in comorbidities, as well as tolerance, monitored for adverse effects including gastrointestinal symptoms (e.g., nausea, vomiting, diarrhea) and discontinuation rates
These include over-the-counter creams that contain capsaicin or salicylates, or a 1% diclofenac gel (Voltaren)
Dehydration is a genuine concern with these medications
This attenuation is explained in part by shifting complier composition: As GLP-1 diffusion expands, the marginal patients induced into treatment become progressively healthier
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