PUFA-PE production depends on coordinated action between acyl coenzyme A synthetase long-chain family member 4 (ACSL4) and lysophospholipid acyltransferase 3 (LPCAT3), which collectively activate and incorporate PUFAs (e.g., docosahexaenoic acid, arachidonic acid) into membrane lipids (43)
Echevarra L, Aupy P, Goyenvalle A
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This not only enhances accumulation at the disease site but also potentially improves cellular uptake and efficacy while minimizing off-target effects and systemic exposure to high doses (151)
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