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Tranexamic acid controls melanogenesisthe process by which the skin produces dark pigmentthereby helping to effectively brighten existing dark circles

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[86] From these results it would appear vitamin E doses used in humans increase the effect of radiotherapy, and super-human doses (above 35,000 IU) may blunt the therapeutic efficacy of radiotherapy

Shibuya K, Fukushima S, Takatsuji H (2009)