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Diabetes Res Clin Pract 170:108532

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Metformin inhibits hepatic gluconeogenesis through AMP-activated protein kinase-dependent regulation of the orphan nuclear receptor SHP

Treatment with galanin or apelin, which are both peptides released in the intestine, results in decreased duodenal contraction via the ENS, which subsequently signals to the hypothalamus, leading to increased hypothalamic NO release and whole-body glucose utilization 79,80

[DOI] [PubMed] [Google Scholar] 102.Imajo K., Kessoku T., Honda Y., Tomeno W., Ogawa Y., Mawatari H., Fujita K., Yoneda M., Taguri M., Hyogo H., et al

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