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GLP-1R KO can lead to increased appetite, contributing to weight gain

Metabolic diseases In addition to muscle and neurodegenerative conditions, alterations in NAD + levels and mitochondrial homeostasis are also observed in aging-associated metabolic diseases, particularly those conditions impacting highly mitochondrially-active tissues such as the kidney and liver 292,293,294

PMC 4473493

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SKIN BARRIER REPAIR

The increase in MMP1 after ultraviolet irradiation of the skin suggests a degradation of these collagen fibers, a loss of mechanical firmness of the skin and the ability to stretch the skin, as well as a decrease in skin elasticity, and all these cause the appearance of signs of skin aging