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117 Additionally, considered as a key antioxidative enzyme, NNT is critical for inducing macrophage inflammatory responses 118 and preventing ROS-induced cytotoxicity in T cells exposed to asbestos that can cause a reduction in antitumor immunity

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Defining these features may help provide a greater understanding of erythropoiesis and reveal molecular targets to regulate this process pharmacologically

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In the GR-catalyzed reaction, reducing equivalents are provided by NADPH

Koutroumpakis E, Triantafyllou E, Livingston J, Song J, Viguet C, Hughes A, Rauschendorfer S, Jeyabal P, Honey TA, Chandra J, Daw NC, Hildebrandt M , Banchs J, Gilchrist S, Roth M, Deswal A, Kleinerman E