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It could be the medication

If your primary goal is significant weight loss (15% or more of body weight), semaglutide or other GLP-1 medications outperform metformin substantially

10.1016/j.yfrne.2014.05.002 43 GarberA.HenryR.RatnerR.Garcia-HernandezP

doi:10.34172/jlms.2021.38 Lago ADN, Fortes ABC, Furtado GS, Menezes CFS, Gonalves LM

"After firing a number of shots across the bow, Novo Nordisk has settled in for the major battle." Novo Nordisk opens new front with patent suit over Hims Wegovy copies reuters.com The latest from Reuters on this tussle between Wegovy maker Novo and telehealth firm Hims: Novo Nordisk sues Hims after $49 weight-loss pill sparks FDA backlash The lawsuit, which covers Novo's weight-loss drugs in pill and injectable forms, highlights the friction between obesity drugmakers and pharmacies that mix the active ingredients, harming the earnings of the original drug manufacturers

Crucially, there is no established evidence base for efficacy at low doses specifically for inflammation, and the dose-response relationship for anti-inflammatory effects is unknown