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The aging process is linked to diminished synthesis and variety of IgA, along with compromised IgA binding specificity to gut bacteria, which disrupts the equilibrium between osteogenesis and osteoclastogenesis and potentially contributes to age-related OP

Zenobi PD, Graf S, Ursprung H, Froesch ER

When you consume iron supplements, especially in higher concentrations or without food, they can alter the gut microbiome and draw excess water into the intestines

doi: 10.1007/BF00400095 39 ZhangX.ZhaoY.ZhangM.PangX.XuJ.KangC.et al

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S., Nishi, H